Engineering translational and physiologically relevant preclinical cancer models to advance women’s health research
The de la Puente Lab develops translational and physiologically relevant preclinical cancer models as tools to recapitulate tumor behavior ex vivo (“out of the living”) with an emphasis in cellular crosstalk, extracellular matrix remodeling, and spatial gradients. We focus on elucidating mechanisms driving chemoresistance and immune evasion in women’s cancer and further developing novel treatment strategies to mitigate their occurrence. Our long-term goal is to accelerate and directly translate our significant insights to aid women suffering from cancer.
Lab News
Publication in Cellular and Molecular Bioengineering: Multicompartmentalized Microvascularized Tumor-on-a-Chip to Study Tumor-Stroma Interactions and Drug Resistance in Ovarian Cancer
Grant Alert!!
The lab has been awarded a 4 year American Cancer Society Research Scholar Grant. We will work on a novel biomarker panel for early detection of ovarian cancer and markers associated with chemoresistance. #Excited #ACS #OvarianCancer #SanfordResearch
Publication in BBA Molecular Cell Research: Reprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype
Dr. de la Puente is featured in the Comic Book Cancer Wars to bring contemporary role models for Hispanic women.
